Cubs vs. Giants odds, predictions, lineups: 2026 MLB Sunday Night Baseball picks

Two longtime NL rivals will square off on ‘Sunday Night Baseball’ as the San Francisco Giants visit the Chicago Cubs. This rubber match is the last of the three match series before they start another three matches next weekend. The Giants (26-39) won Friday by a score of 18-3, before the Cubs (34-31) took Saturday’s contest, 3-2, in extra innings. Trevor McDonald (2-3, 4.50 ERA) will pitch in San Francisco, facing Chicago’s Jameson Taillon (2-5, 5.13 ERA).

First pitch is at 8:30 pm ET from Wrigley Field in Chicago. The latest Giants vs. Cubs odds list Chicago as a -116 favorite on the money line (risk $116 to win $100). The over/under total for the run is 8. Before making any Cubs vs. Giants or MLB predictions, be sure to see Sunday Night Baseball predictions and betting tips from SportsLine’s proven computer model.

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The SportsLine Projection Model simulates every MLB game 10,000 times, and enters Week 11 with the Red Heat 17-5 (77%) in all MLB top-rated picks. It was also very effective at making home run prop picks in 2025, returning nearly 30 units of profit. Anyone following their MLB betting picks at sportsbooks and betting sites would have seen strong returns.

Now, the model has set her sights on Giants vs. The Cubs also recently locked in their picks and MLB predictions. You can head over to SportsLine now to see the model selection. Here are a few MLB and Cubs vs. Giants:

High Lambs vs. Giants predictions

After 10,000 plays of Giants vs. Cubs, the model is walking Over 8 runs. Both teams are tied this season, with the Over having a 36-28-1 record in Cubs games and a 32-28-5 mark in Giants games. The Over also has an impressive record of 18-4 (81%) in Giants games against average teams that win 46-54% of their games, as is the case with Chicago.

Both starting pitchers have ERAs of at least 4.50, and McDonald has averaged just 5.0 IP over his last three starts, meaning San Fran’s bullpen, which has the fourth-highest ERA in the NL, should be heavily involved. As for Taillon, he won’t benefit from the shade hitters in day games have to face, and the pitcher’s ERA in night games is 5.68 this season. With a combined prediction of 9.1, Over is a strong choice sports betting over/under. Get the pick of the Cubs vs. Giants on SportsLine.

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How to make Giants vs. Cubs picks

After simulating every pitch of the Cubs vs. Giants 10,000 times, the model also says that one side of the money line has all the value. You can find that pick at SportsLine.

So who wins Giants vs. Cubs, and which side of the money line has all the value? Visit SportsLine now to see which side you should jump on, everything from the model that crushed its MLB picks, and find out.